Collagen Stimulating Injection (Biostimulators)

Naturally boost collagen and rejuvenate your skin Discover hydrated skin and radiance
Collagen Stimulating Injection (Biostimulators)


Not just another dermal filler! Revolumise, and naturally rejuvenate the face and neck areas. Rebuild better hydration with Collagen stimulators with The R Clinic


Collagen stimulating fillers are different in longevity & application compared to shorter-acting hyaluronic acid fillers. These groups of fillers give an immediate effect followed by long-term collagen stimulation. The most popular collagen-stimulating fillers in Australia include PLLA & calcium hydroxylapatite. It is commonly used in the jawline, and necklines & for volume replacement in the hands.

When collagen stimulating injections paired with the right skincare products, it can help you maintain a more youthful appearance for many years to come.

How it works

Not just another dermal filler, collagen stimulating injections otherwise known as collagen bio-stimulators are considered the next generation of cosmetic fillers. It contains a gel matrix which gives instant volume enhancement, while forming a ‘scaffold’ in the dermal layer of the skin which triggers the production of collagen and elastin. These products can help to restore volume to crepey skin and also provide a subtle lift by stimulating the underlying dermal tissues to resume collagen production. Your skin will benefit from both a restoration in volume and also improvement in skin structure and hydration.


Why we use Biostimulators?

Collagen stimulating injections are ideal for treating larger areas that require rejuvenation such as the lower face and neck. These injections can fill deep lines and folds and provide significant lift and volume in areas like the cheeks, jawline, temples, and mid-face. They are also used in areas beyond the face, such as the backs of the hands.

Collagen stimulators give patients healthy, natural and subtle rejuvenation that develops slowly over time. If you’re looking for maximum results that develop discreetly, you will likely benefit from a collagen stimulator treatment. Improved volume of the skin, smoother skin and better-hydrated skin in the face, neck and hands are all potential outcomes from collagen stimulator treatments.

Expected result

Patients can expect to see results directly after their collagen stimulating injections, but these will slowly subside as the treatment takes effect. You will gradually see changes in your face as new collagen is formed, with the most dramatic changes being visible 8 weeks after your treatment. By 8 weeks, new strands of collagen will have begun to form, creating the appearance of fuller skin.

Additional treatments may be done after six months; however, a lower amount of product will be used the second time as the collagen production process will still be taking place after the initial treatment by this stage. Generally, top-up treatments may be needed about 2-4 times every 12 months to produce the best results.

  • Treatment Time – 40 Mins
  • Discomfort – Mild
  • Recovery – 24 Hours

Preparation and Aftercare


  • One week prior to the treatment – Avoid blood thinning over-the-counter medications (such as aspirin, ibuprofen) or supplements (such as St. John’s Wort, Gingko biloba, primrose oil, garlic, ginseng).
  • Two days prior to the treatment – avoid topical products such as Tretinoin, Retinol, Glycolic Acid.
  • Do not drink alcoholic beverages 24 hours prior.

During procedure

Topical or local anesthetics may be used to minimize discomfort. A cannula is used to deposit the collagen stimulators under the skin in long threads. The area is then massaged to distribute the product evenly. Once injected, the collagen stimulators will prompt the underlying tissues of the skin to produce more collagen, creating anti-aging effects over time.


There may be some redness, bruising and swelling post-treatment, but it will fade and disappear within the week. It is recommended that patients massage the area x5 times daily for up to 5 days to ensure the product remains evenly distributed.

Avoid alcohol, caffeine, hot drinks, and spicy food for 24 hours, as these may exacerbate bruising and swelling.

Avoid exercise or excessive exertion, excess sun exposure, or sauna use for 24 hours.

Avoid medications such as aspirin or nurofen for 1-2 weeks as they are blood thinning agents and may exacerbate bruising.

Apply cold compresses as required to the area injected for up to 6 hours after the treatment. This will prevent or help to alleviate any bruising.

If you suffer any allergic responses, prolonged generalised symptoms or if any lumps/unevenness persists after 5-7 days, please contact your cosmetic practitioner for advice.

Pricing & Packages

Collagen Stimulators

  • Collagen Stimulator – Face or Neck $950
  • Collagen Stimulator – Face & Neck $1800
  • Hand Rejuvenation $950


Have further questions or want to learn more?

Contact Us
What Can Collagen Stimulating Injections Treat?

Here are some of the most common areas and concerns that can be treated with collagen stimulating injections: 

  • Cheeks: Add more volume to the cheeks to reverse a sunken or sagging appearance 
  • Décolletage: Smooth out wrinkles on the chest 
  • Nasolabial Folds: Plump up the line between your nose and mouth 
  • Recessed Temples: Plump out temples to create a more youthful appearance 
  • Sagging Jowls: Create a more defined jawline 
  • Hands: Rejuvenate hands by adding volume and improving skin texture 
  • Neck: Tighten the neck and improve skin quality 
  • Buttock: Enhance volume and correct dimples and skin tone 
  • Stretch Marks: Lessen the stretch marks and tighten the skin 
Is there any downtime after being treated with collagen stimulators?

There is no downtime required after being treated with Collagen stimulators, and you are not required to schedule any time off of work. You can go straight back to work can resume normal activities immediately; However, exercise is not recommended for 24-hours after injections. Mild swelling, red bumps or bruising may appear after injections; However, any redness tends to dissipate shortly after treatment and makeup can be gently applied. 

Who is NOT a candidate for Collagen stimulator injections?

During your consultation an assessment will be made to ensure who is the right candidate for Collagen stimulator injections. This treatment is not safe for those with bleeding disorders or other health problems. Those who are pregnant, or breastfeeding are not a candidate for Collagen stimulators injections. 

What are the benefits of collagen stimulating fillers over hyaluronic acid dermal fillers?

Collagen stimulating fillers has 3 distinct advantages when employed correctly. Firstly longevity, collagen stimulating fillers can last upward of 5+ years, compared to 2+ year with HA fillers. Secondly volume & cost, in areas such as temples and jawline, it can provide better lifting capacity with less volume. Thirdly, it has additional effect on skin rejuvenation and can be used as a treatment for hand rejuvenation. 

What are the risks of collagen stimulating fillers?

Careful injecting with excellent product & anatomical knowledge will markedly reduce but not eliminate side effects. HA or hyaluronic acid fillers are reversible with an enzyme called Hyalase, whilst collagen stimulating fillers such as PLLA (Poly-L-Lactic-Acid) & calcium hydroxyl apatite do not have a reliable reversal agent.  

Delayed nodules, infection, & biofilm are very rare side effects. The decision to employ collagen stimulating fillers is based upon calculations of risks & benefits taking into consideration clinical findings, technique, anatomy, & dilution. 

What Is the recovery process after Collagen stimulator injections?

After your Collagen stimulator injections, you may experience redness and swelling, bruising may also be visible. You may experience tenderness at injection site for a few days after your treatment. Depending upon the areas treated and products used, you may feel “firmness” in the treated areas for 1 to 2 weeks after treatment. Over time, the areas will soften and “settle.” For discomfort you may take Tylenol. Arnica creams can be topically applied to aid bruising, swelling and pain after treatment.

Is the treatment painful?

Treatments are super comfortable as we normally reconstitute these fillers with local anaesthetic agents. These biostimulator fillers, when formulated correctly, give the same sensation as with hyaluronic acids. 

How long do collagen stimulators normally last?

Calcium hydroxyl apatite & poly-L-lactic acid fillers typically last between 36 to 60 months, depending on the area treated, dilution, & individual factors (such as your immune system & metabolism). 

In hyper-dilute concentrations the longevity ranges between 1 to 3+ years. 

Best paired with